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Review
. 2008 Jan;43(1):1-4.
doi: 10.1016/j.exger.2007.09.008. Epub 2007 Oct 1.

Caenorhabditis elegans 2007: the premier model for the study of aging

Thomas E Johnson  1
Affiliations
Review

Caenorhabditis elegans 2007: the premier model for the study of aging

Thomas E Johnson. Exp Gerontol. 2008 Jan.

Abstract

This is the 25th anniversary of the discovery of extended longevity mutants in Caenorhabditis elegans. About one hundred papers describing results from studies on C. elegans in aging research appeared this year. Many themes were pursued including dietary restriction, daf-9 action, the role of proteolysis and autophagy, and the continued search for more Age mutants. I use the word "modulate" not "regulate" so as to be consistent with the evolutionary theory of aging, which is also consistent with the empirical findings of all extended longevity (Age) mutants. These Age mutants universally result from deficits in known physiologic systems, rather than in some process designed to kill the animal in old age.

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References

    1. Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature. 2007;447:545–549. - PubMed
    1. Brignull HR, Morley JF, Morimoto RI. The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. Adv Exp Med Biol. 2007;594:167–189. - PubMed
    1. Brouë F, Liere P, Kenyon C, Baulieu EE. A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell. 2007;6:87–94. - PubMed
    1. Chen D, Pan KZ, Palter JE, Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell. 2007;6:525–533. - PMC - PubMed
    1. Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science. 2006;313:1604–1610. - PubMed

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