Abstract
The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate (1), rosmarinic acid (2) and methyl rosmarinate (3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10 microg/ml.
MeSH terms
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Angiotensin-Converting Enzyme Inhibitors / chemistry*
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Angiotensin-Converting Enzyme Inhibitors / pharmacology*
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Animals
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Caffeic Acids / chemistry
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Caffeic Acids / pharmacology
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Cinnamates / chemistry
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Cinnamates / pharmacology
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Depsides / chemistry
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Depsides / pharmacology
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Isodon / chemistry*
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Lung / enzymology
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Peptidyl-Dipeptidase A / drug effects
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Peptidyl-Dipeptidase A / isolation & purification
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Peptidyl-Dipeptidase A / metabolism
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Rabbits
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Rosmarinic Acid
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Caffeic Acids
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Cinnamates
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Depsides
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Plant Extracts
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ethyl caffeate
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Peptidyl-Dipeptidase A