Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa

Phytomedicine. 2008 May;15(5):386-8. doi: 10.1016/j.phymed.2007.09.013. Epub 2007 Oct 30.

Abstract

The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate (1), rosmarinic acid (2) and methyl rosmarinate (3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10 microg/ml.

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / chemistry*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology*
  • Animals
  • Caffeic Acids / chemistry
  • Caffeic Acids / pharmacology
  • Cinnamates / chemistry
  • Cinnamates / pharmacology
  • Depsides / chemistry
  • Depsides / pharmacology
  • Isodon / chemistry*
  • Lung / enzymology
  • Peptidyl-Dipeptidase A / drug effects
  • Peptidyl-Dipeptidase A / isolation & purification
  • Peptidyl-Dipeptidase A / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Rabbits
  • Rosmarinic Acid

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Caffeic Acids
  • Cinnamates
  • Depsides
  • Plant Extracts
  • ethyl caffeate
  • Peptidyl-Dipeptidase A