Abstract
In the present study, we have examined the hypoglycemic effect of maslinic acid (MA) in KK-A(y) mice, an animal model of genetic type-2 diabetes. MA (10 mg/kg body wt) reduced the blood glucose levels in KK-A(y) mice at 4 h after a single oral dose. KK-A(y) mice receiving MA at daily dosages of 10 mg/kg and 30 mg/kg for 2 weeks showed a significant reduction in the blood glucose levels. Furthermore, the results also showed that MA might modulate glucose metabolism partially through reducing insulin resistance in KK-A(y) mice. Taken together, MA may hold great promise as a natural therapeutic agent for treatment of type 2 diabetes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adiponectin / blood
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Administration, Oral
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Alanine Transaminase / blood
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Alkaline Phosphatase / blood
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Animals
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Aspartate Aminotransferases / blood
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Blood Glucose / metabolism*
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Diabetes Mellitus, Experimental / metabolism*
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Diabetes Mellitus, Type 2 / metabolism
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Dose-Response Relationship, Drug
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Fasting
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Glucose Tolerance Test
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Hypoglycemic Agents / administration & dosage
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology*
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L-Lactate Dehydrogenase / blood
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Liver Glycogen / analysis
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Male
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Mice
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Mice, Inbred Strains
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Molecular Structure
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Triterpenes / administration & dosage
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Triterpenes / chemistry
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Triterpenes / pharmacology*
Substances
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Adiponectin
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Blood Glucose
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Hypoglycemic Agents
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Liver Glycogen
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Triterpenes
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maslinic acid
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L-Lactate Dehydrogenase
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Aspartate Aminotransferases
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Alanine Transaminase
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Alkaline Phosphatase