Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors

Kidney Int. 2008 Jan;73(2):192-9. doi: 10.1038/ Epub 2007 Oct 31.


Dietary casein promotes a progressive decline in the glomerular filtration rate (GFR) of remnant kidneys associated with metabolic acidosis and an endothelin-mediated increase in renal acidification. We tested whether diets that affect the acid-base status contributes to the decline of GFR through endothelin receptors in rats with a remnant kidney. Rats on a casein diet had metabolic acidosis at baseline and developed a progressive decline in GFR after renal mass reduction. Dietary sodium bicarbonate but not sodium chloride ameliorated metabolic acidosis and prevented the decrease in GFR but only after the sodium bicarbonate-induced increase in blood pressure was treated. Dietary soy protein did not induce baseline metabolic acidosis and rats with remnant kidney on a soy diet had no decrease in their GFR. By contrast, rats with a remnant kidney on soy protein given dietary acid developed metabolic acidosis and a decreased GFR. This decline in GFR was prevented in either case by endothelin A but not endothelin A/B receptor antagonism. Our study suggests that the casein-induced decline in GFR of the remnant kidney is mediated by metabolic acidosis through endothelin A receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acidosis / physiopathology*
  • Animals
  • Bicarbonates / pharmacology
  • Blood Pressure
  • Carbon Dioxide / blood
  • Caseins / adverse effects
  • Dietary Proteins / adverse effects*
  • Endothelin-1 / urine
  • Glomerular Filtration Rate*
  • Male
  • Nephrectomy*
  • Rats
  • Receptors, Endothelin / physiology*
  • Sodium Chloride / pharmacology


  • Bicarbonates
  • Caseins
  • Dietary Proteins
  • Endothelin-1
  • Receptors, Endothelin
  • Carbon Dioxide
  • Sodium Chloride