From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway

J Cell Biochem. 2007 Dec 15;102(6):1400-4. doi: 10.1002/jcb.21609.


Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • E2F Transcription Factors / genetics
  • E2F Transcription Factors / metabolism*
  • Genes, Tumor Suppressor
  • Humans
  • Models, Biological
  • Multigene Family
  • Retinoblastoma* / genetics
  • Retinoblastoma* / prevention & control
  • Retinoblastoma-Like Protein p107 / genetics
  • Retinoblastoma-Like Protein p107 / metabolism*
  • Retinoblastoma-Like Protein p130 / genetics
  • Retinoblastoma-Like Protein p130 / metabolism*
  • S Phase*


  • E2F Transcription Factors
  • Retinoblastoma-Like Protein p107
  • Retinoblastoma-Like Protein p130