Abstract
Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression.
Copyright (c) 2007 Wiley-Liss, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Cycle / genetics
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E2F Transcription Factors / genetics
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E2F Transcription Factors / metabolism*
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Genes, Tumor Suppressor
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Humans
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Models, Biological
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Multigene Family
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Retinoblastoma* / genetics
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Retinoblastoma* / prevention & control
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Retinoblastoma-Like Protein p107 / genetics
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Retinoblastoma-Like Protein p107 / metabolism*
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Retinoblastoma-Like Protein p130 / genetics
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Retinoblastoma-Like Protein p130 / metabolism*
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S Phase*
Substances
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E2F Transcription Factors
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Retinoblastoma-Like Protein p107
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Retinoblastoma-Like Protein p130