A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors

Nano Lett. 2007 Dec;7(12):3759-65. doi: 10.1021/nl072209h. Epub 2007 Nov 3.

Abstract

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / therapeutic use
  • Biological Transport
  • Cell Hypoxia
  • Drug Delivery Systems / methods
  • Humans
  • Macrophages / drug effects
  • Macrophages / ultrastructure
  • Monocytes / drug effects
  • Monocytes / ultrastructure
  • Nanoparticles / administration & dosage*
  • Nanoparticles / therapeutic use
  • Neoplasms / drug therapy*
  • Spectrophotometry

Substances

  • Antineoplastic Agents