Integrin regulation of caveolin function

J Cell Mol Med. Sep-Oct 2007;11(5):969-80. doi: 10.1111/j.1582-4934.2007.00109.x.

Abstract

Caveolae are unique organelles that are found in the plasma membrane of many cell types. They participate in various processes such as lipid recycling, cellular signalling and endocytosis. A variety of signalling molecules localize to caveolae in response to various stimuli, providing a potential mechanism for the spatial regulation of signal transduction pathways. Caveolin-1, a constitutive protein of caveolae, has been implicated in the regulation of cell growth, lipid trafficking, endocytosis and cell migration. Phosphorylation of caveolin-1 on Tyr 14 is involved in integrin-regulated caveolae trafficking and also in signalling at focal adhesions in migrating cells. In this review, we focus on recent studies that describe the role of caveolin-1 in integrin signal transduction, and how this interplay links extracellular matrix anchorage to cell proliferation, polarity and directional migration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caveolins / metabolism*
  • Cell Movement
  • Endocytosis
  • Humans
  • Integrins / metabolism*
  • Membrane Microdomains / metabolism
  • Signal Transduction

Substances

  • Caveolins
  • Integrins