Serum calcium and cognitive function in old age

J Am Geriatr Soc. 2007 Nov;55(11):1786-92. doi: 10.1111/j.1532-5415.2007.01418.x.


Objectives: To determine whether serum calcium is associated with cognitive function in elderly individuals in the general population.

Design: Prospective follow-up study of two independent, population-based cohorts.

Setting: The Rotterdam Study (median follow-up 11 years) and the Leiden 85-plus Study (median follow-up 5 years).

Participants: Three thousand nine hundred ninety-four individuals, mean age 71, from the Rotterdam Study and 560 individuals, all aged 85, from the Leiden 85-plus Study.

Measurements: Global cognitive function was assessed in both cohorts using the Mini-Mental State Examination; attention, psychomotor speed, and memory function were assessed in the Leiden 85-plus Study only. Linear regression and linear mixed models were used for statistical analyses.

Results: In the Rotterdam Study, high serum calcium was associated with worse global cognitive function at baseline (P<.05) and a faster rate of decline in cognitive function during follow-up (P=.005) in individuals aged 75 and older but not in younger individuals. In the Leiden 85-plus Study, high serum calcium was associated with worse global cognitive function from age 85 through 90 (P<.001). This observation also held for the specific cognitive domains tested (all P<.01). These results did not change when individuals with serum calcium levels greater than normal (>2.55 mmol/L) were excluded from the analyses.

Conclusion: In the general population, high serum calcium levels are associated with faster decline in cognitive function over the age of 75.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Calcium / blood*
  • Cognition Disorders / blood*
  • Cognition Disorders / diagnosis
  • Cohort Studies
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Geriatric Assessment
  • Humans
  • Male
  • Mental Status Schedule
  • Netherlands
  • Neuropsychological Tests
  • Prospective Studies
  • Statistics as Topic


  • Calcium