Limiting the proliferation of polyploid cells

Cell. 2007 Nov 2;131(3):437-40. doi: 10.1016/j.cell.2007.10.024.


Many errors in cell division lead to failure of cytokinesis and the generation of tetraploid cells. Given that tetraploidy can have deleterious consequences, such as genetic instability, we discuss the mechanisms that may have evolved to directly or indirectly prevent the proliferation of these cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Proliferation
  • Cells / cytology*
  • Cells / metabolism*
  • Humans
  • Polyploidy*
  • Tumor Suppressor Protein p53 / metabolism


  • Tumor Suppressor Protein p53