The evolutionary consequences of polyploidy

Cell. 2007 Nov 2;131(3):452-62. doi: 10.1016/j.cell.2007.10.022.


Polyploidization, the addition of a complete set of chromosomes to the genome, represents one of the most dramatic mutations known to occur. Nevertheless, polyploidy is well tolerated in many groups of eukaryotes. Indeed, the majority of flowering plants and vertebrates have descended from polyploid ancestors. This Review examines the short-term effects of polyploidization on cell size, body size, genomic stability, and gene expression and the long-term effects on rates of evolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Body Size
  • Cell Size
  • Genes, Duplicate
  • Genomic Instability
  • Humans
  • Polyploidy*