Progressive multifocal leukoencephalopathy as first manifestation of sarcoidosis

Clin Neurol Neurosurg. 2008 Feb;110(2):186-9. doi: 10.1016/j.clineuro.2007.09.012. Epub 2007 Nov 5.


Progressive multifocal leukoencephalopathy (PML) is a demyelinating neurologic disorder caused by a polyomavirus, called JC virus. PML affects mainly immunocompromised hosts. We report a case of PML as first manifestation of sarcoidosis in a previously healthy man. Treatment with cidofovir, resulted in a neurological and radiological stabilization. To our knowledge the association of PML and sarcoidosis without previous immunosuppressive treatment has only been described in a few cases, none of them were treated with cidofovir.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiviral Agents / therapeutic use
  • Cidofovir
  • Cytosine / analogs & derivatives
  • Cytosine / therapeutic use
  • Humans
  • Leukoencephalopathy, Progressive Multifocal / diagnosis*
  • Leukoencephalopathy, Progressive Multifocal / drug therapy
  • Leukoencephalopathy, Progressive Multifocal / etiology*
  • Male
  • Organophosphonates / therapeutic use
  • Sarcoidosis / complications*
  • Sarcoidosis / diagnosis*
  • Sarcoidosis / therapy


  • Antiviral Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir