Nisin-triggered activity of Lys44, the secreted endolysin from Oenococcus oeni phage fOg44

J Bacteriol. 2008 Jan;190(1):457-61. doi: 10.1128/JB.01195-07. Epub 2007 Nov 2.

Abstract

The intrinsic resistance of Oenococcus oeni cells to the secreted endolysin from oenophage fOg44 (Lys44) was investigated. Experiments with several antimicrobials support the hypothesis that the full activity of Lys44 requires sudden ion-nonspecific dissipation of the proton motive force, an event undertaken by the fOg44 holin in the phage infection context.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriophages / pathogenicity
  • Bacteriophages / physiology*
  • Cell Wall / physiology
  • Cell Wall / virology
  • DNA / genetics
  • DNA, Viral / genetics
  • Immunity, Innate
  • Lactobacillaceae / physiology
  • Lactobacillaceae / virology*
  • Nisin / metabolism*
  • Viral Proteins / physiology*

Substances

  • DNA, Viral
  • Viral Proteins
  • Nisin
  • DNA