Control of key metabolic intersections in Bacillus subtilis

Nat Rev Microbiol. 2007 Dec;5(12):917-27. doi: 10.1038/nrmicro1772.


The remarkable ability of bacteria to adapt efficiently to a wide range of nutritional environments reflects their use of overlapping regulatory systems that link gene expression to intracellular pools of a small number of key metabolites. By integrating the activities of global regulators, such as CcpA, CodY and TnrA, Bacillus subtilis manages traffic through two metabolic intersections that determine the flow of carbon and nitrogen to and from crucial metabolites, such as pyruvate, 2-oxoglutarate and glutamate. Here, the latest knowledge on the control of these key intersections in B. subtilis is reviewed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bacillus subtilis / enzymology
  • Bacillus subtilis / metabolism*
  • Bacterial Proteins / metabolism
  • Carbon / metabolism
  • Citric Acid Cycle
  • DNA-Binding Proteins / metabolism
  • Glutamic Acid / metabolism
  • Ketoglutaric Acids / metabolism
  • Nitrogen / metabolism
  • Pyruvic Acid / metabolism
  • Repressor Proteins / metabolism
  • Transcription Factors / metabolism


  • Bacterial Proteins
  • DNA-Binding Proteins
  • Ketoglutaric Acids
  • Repressor Proteins
  • ScgR protein, Bacillus subtilis
  • Transcription Factors
  • catabolite control proteins, bacteria
  • Glutamic Acid
  • Carbon
  • Pyruvic Acid
  • Nitrogen