Adoptive cellular immunotherapy for viral diseases

Bone Marrow Transplant. 2008 Jan;41(2):193-8. doi: 10.1038/sj.bmt.1705906. Epub 2007 Nov 5.


Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can reconstitute antiviral immunity in recipients and be effective both in preventing and treating cytomegalovirus, Epstein-Barr virus and adenovirus infection. Current efforts are focused on providing protection toward a broader range of viruses safely, rapidly and effectively.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • DNA Virus Infections / etiology
  • DNA Virus Infections / therapy*
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Humans
  • Immunotherapy, Adoptive / methods*
  • T-Lymphocytes, Cytotoxic / transplantation*
  • Virus Latency