Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis

Clin Rheumatol. 2008 Jun;27(6):709-12. doi: 10.1007/s10067-007-0770-3. Epub 2007 Nov 3.

Abstract

This prospective study analyzed the frequency of HLA-B27 and its alleles in 102 Brazilian patients with psoriatic arthritis (PsA). The association of the HLA-B27 alleles with these variants was compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%), and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%), and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27-positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5%), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Arthritis, Psoriatic / ethnology*
  • Arthritis, Psoriatic / genetics*
  • Blacks / statistics & numerical data*
  • Brazil / epidemiology
  • Female
  • Genetic Predisposition to Disease / ethnology
  • HLA-B27 Antigen / genetics*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Prospective Studies
  • Whites / statistics & numerical data*

Substances

  • HLA-B27 Antigen