Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications

J Am Chem Soc. 2007 Nov 28;129(47):14530-1. doi: 10.1021/ja073790m. Epub 2007 Nov 6.


We have developed a versatile nanoparticle construct using a compact cysteine coating on a CdSe(ZnCdS) core(shell) nanocrystal (QD-Cys) that is biologically compatible, exceptionally compact, highly fluorescent, and easily functionalized. The small hydrodynamic diameter of QD-Cys ( approximately 6 nm) allows for renal clearance of these nanoparticles in rat models. Moreover, the ability to directly conjugate to QD-Cys opens up the possibility of functionalized nanocrystals for in vivo targeted imaging, in which small targeting molecules can be appended to QD-Cys, and unbound QDs can be rapidly cleared to achieve high signal/noise ratios and to reduce background toxicity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cadmium / chemistry*
  • Cadmium / pharmacokinetics*
  • Cadmium Compounds / chemistry*
  • Cadmium Compounds / pharmacokinetics*
  • Cysteine / chemistry*
  • Molecular Structure
  • Quantum Dots*
  • Rats
  • Selenium Compounds / chemistry*
  • Selenium Compounds / pharmacokinetics*
  • Sulfides / chemistry*
  • Sulfides / pharmacokinetics*
  • Zinc / chemistry*
  • Zinc / pharmacokinetics*


  • Cadmium Compounds
  • Selenium Compounds
  • Sulfides
  • Cadmium
  • cadmium selenide
  • Zinc
  • Cysteine