DisSIRTing on LXR and cholesterol metabolism

Cell Metab. 2007 Nov;6(5):343-5. doi: 10.1016/j.cmet.2007.10.003.


The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Biological Transport
  • Cholesterol / metabolism*
  • Humans
  • Lipid Metabolism
  • Models, Biological
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Sirtuins / metabolism*


  • Receptors, Cytoplasmic and Nuclear
  • Cholesterol
  • Sirtuins