Cell Metab. 2007 Nov;6(5):348-51. doi: 10.1016/j.cmet.2007.10.005.


Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and comparison of thousands of chemical entities, which has lead to an expansion of small molecule biochemistry studies in bacteria, plants, and mammals. Continued development of these analytical platforms will accelerate the widespread use of metabolomics and allow further integration of small molecules into systems biology. Here, recent studies using metabolomics in xenobiotic metabolism and genetically modified mice are highlighted.

MeSH terms

  • Animals
  • Genotype
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Mass Spectrometry
  • Metabolic Networks and Pathways / genetics
  • Metabolic Networks and Pathways / physiology
  • Metabolism*
  • Mice
  • Mice, Knockout
  • PPAR alpha / genetics
  • PPAR alpha / metabolism
  • Software*


  • PPAR alpha