Membrane dynamics and spatial distribution of Salmonella-containing vacuoles

Trends Microbiol. 2007 Nov;15(11):516-24. doi: 10.1016/j.tim.2007.10.002. Epub 2007 Nov 5.

Abstract

Salmonella enterica are facultative intracellular bacteria that cause intestinal and systemic diseases, and replicate within host cells in a membrane-bound compartment, the Salmonella-containing vacuole. Intravacuolar bacterial replication depends on spatiotemporal regulated interactions with host cell vesicular compartments. Recent studies have shown that type III secretion effector proteins control both the vacuolar membrane dynamics and intracellular positioning of bacterial vacuoles. The functions of these effectors, which are beginning to be understood, disclose a complex hijacking of host cell microtubule motors--kinesins and dynein--and regulators of their function, and suggest interactions with the Golgi complex. Here, we discuss current models describing the mode of action of Salmonella type III secretion effector proteins involved in these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / metabolism*
  • Dyneins / metabolism*
  • Endosomes / metabolism
  • Endosomes / microbiology
  • Golgi Apparatus / metabolism
  • Golgi Apparatus / microbiology*
  • Humans
  • Intracellular Membranes / physiology
  • Kinesin / metabolism*
  • Models, Biological
  • Salmonella / pathogenicity
  • Salmonella / physiology*
  • Salmonella Infections / microbiology*
  • Vacuoles / metabolism
  • Vacuoles / microbiology*
  • Vacuoles / physiology

Substances

  • Bacterial Proteins
  • Dyneins
  • Kinesin