Proton NMR imaging of cerebral blood flow using H2(17)O

Magn Reson Med. 1991 Nov;22(1):154-8. doi: 10.1002/mrm.1910220116.


Cerebral blood flow was quantitatively mapped by monitoring the cerebral washout of H2(17)O using rapid, single-shot proton NMR imaging. H2(17)O acts as a freely diffusible contrast agent for proton imaging via its scalar-coupled term, enhancing T2 relaxation. Measured values for CBF ranged from 29 to 106 ml/min/100 g over a range of arterial pCO2 between 23 and 81 Torr.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cerebrovascular Circulation*
  • Dogs
  • Magnetic Resonance Spectroscopy*
  • Oxygen Isotopes
  • Water


  • Oxygen Isotopes
  • Water