[Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis]

Naoto Tamura; Kazuhiko Haruta

doi:10.2177/jsci.30.369

[Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis]

Nihon Rinsho Meneki Gakkai Kaishi. 2007 Oct;30(5):369-74. doi: 10.2177/jsci.30.369.

[Article in Japanese]

Authors

Naoto Tamura¹, Kazuhiko Haruta

Affiliation

¹ Department of Internal Medicine and Rheumatology Juntendo University School of Medicine.

PMID: 17984576
DOI: 10.2177/jsci.30.369

Abstract

Activation of PI3K is a key step of intracellular signaling involved in many cellular functions. PI3K inhibitors have shown anti-rheumatic effects on arthritis model in mice. PI3K is a potential therapeutic target of rheumatoid arthritis.

Publication types

Review

MeSH terms

Animals
Arthritis, Rheumatoid / drug therapy*
Humans
Phosphatidylinositol 3-Kinases / physiology
Phosphoinositide-3 Kinase Inhibitors*
Quinoxalines / therapeutic use
Thiazolidinediones / therapeutic use

Substances

5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione
Phosphoinositide-3 Kinase Inhibitors
Quinoxalines
Thiazolidinediones