The immunobiology of corneal transplantation

Transplantation. 2007 Oct 15;84(7):806-13. doi: 10.1097/


Corneal allotransplantation is highly successful in the short term, but much less successful in the longer term. Many corneal grafts in recipients with corneal neovascularization or the sequelae of ocular inflammation undergo irreversible rejection, despite topical immunosuppression with glucocorticosteroids. Sensitization to cornea-derived alloantigen proceeds by both direct and indirect routes, but the anatomic location of sensitization remains unclear. Multiple and redundant mechanisms operate in the effector phase of corneal graft rejection, which is largely cell-mediated rather than antibody-mediated. Human leukocyte antigen matching may improve outcomes in high-risk patients but systemic immunosuppression is frequently ineffective and is seldom used.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cornea / immunology*
  • Corneal Diseases / therapy
  • Corneal Neovascularization / pathology
  • Corneal Transplantation / methods*
  • Graft Survival
  • HLA Antigens / chemistry
  • Histocompatibility Testing / methods
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Inflammation
  • Time Factors
  • Transplantation, Homologous
  • Treatment Outcome


  • HLA Antigens
  • Immunosuppressive Agents