Abstract
The immune response to respiratory syncytial virus (RSV) infection has fascinated and frustrated investigators for decades. After adverse responses to early attempts at vaccination, it became popularly held that disease following infection was related to overly aggressive immune responses. However, recent data illustrate that severe forms of disease are related to inadequate, rather than hyperresponsive, adaptive immune reactions. Thus, recovery from primary (and perhaps later) RSV infection is dependent on the quality of innate immune responses. These findings should have enormous significance to the development of vaccines and antiviral compounds.
MeSH terms
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Antibodies, Viral / biosynthesis
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Cytokines / immunology
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Cytokines / metabolism*
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Humans
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Immunity, Cellular
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Immunity, Innate
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Infant
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Inflammation Mediators / immunology
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Inflammation Mediators / metabolism
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Pulmonary Surfactant-Associated Proteins / metabolism
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Respiratory Syncytial Virus Infections / immunology*
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Respiratory Syncytial Virus Infections / virology
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Respiratory Syncytial Virus, Human / immunology*
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Respiratory System / immunology*
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Respiratory System / virology
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Respiratory Tract Infections / immunology*
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Respiratory Tract Infections / virology
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Toll-Like Receptors / immunology
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Toll-Like Receptors / metabolism*
Substances
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Antibodies, Viral
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Cytokines
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Inflammation Mediators
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Pulmonary Surfactant-Associated Proteins
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Toll-Like Receptors