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. 2008 Jan;36(Database issue):D230-3.
doi: 10.1093/nar/gkm950. Epub 2007 Nov 5.

LOCATE: A Mammalian Protein Subcellular Localization Database

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Free PMC article

LOCATE: A Mammalian Protein Subcellular Localization Database

Josefine Sprenger et al. Nucleic Acids Res. .
Free PMC article

Abstract

LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of mouse and human proteins. Over the past 2 years, the data in LOCATE have grown substantially. The database now contains high-quality localization data for 20% of the mouse proteome and general localization annotation for nearly 36% of the mouse proteome. The proteome annotated in LOCATE is from the RIKEN FANTOM Consortium Isoform Protein Sequence sets which contains 58 128 mouse and 64 637 human protein isoforms. Other additions include computational subcellular localization predictions, automated computational classification of experimental localization image data, prediction of protein sorting signals and third party submission of literature data. Collectively, this database provides localization proteome for individual subcellular compartments that will underpin future systematic investigations of these regions. It is available at http://locate.imb.uq.edu.au/

Figures

Figure 1.
Figure 1.
Transmembrane topology and predicted motifs and domains display.
Figure 2.
Figure 2.
Organelle proteomics—defining the protein complement of individual organelles.

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