Potential roles for estrogen regulation of telomerase activity in aging

Ann N Y Acad Sci. 2007 Oct;1114:48-55. doi: 10.1196/annals.1396.023.


Estrogen regulates tissue development, function, and aging by regulating expression of critical genes. Recent studies suggest that estrogen promotes cell proliferation by stimulating telomerase activity, an enzyme that plays a key role in extending cell life span. In some estrogen-responsive tissues, estrogen appears important in regulating telomerase activity in vivo. Further characterization will provide a greater understanding of the link between estrogen, telomerase, and aging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / metabolism*
  • Aging / physiology
  • Animals
  • Estrogens / physiology*
  • Humans
  • Telomerase / metabolism*


  • Estrogens
  • Telomerase