Neonatal diabetes

Endocr Dev. 2007:11:70-82. doi: 10.1159/000111059.


ATP-sensitive potassium (KATP) channels are inhibited by intracellular ATP and activated by MgADP. As a consequence, they couple the metabolic state of the cell to its electrical activity. In pancreatic Beta-cells KATP channels regulate glucose-dependent insulin secretion and are the target for sulphonylurea drugs clinically employed in the treatment of type 2 diabetes. This review discusses recent advances in our understanding of the role of KATP channels in permanent neonatal diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diabetes Mellitus / congenital*
  • Diabetes Mellitus / genetics*
  • Diabetes Mellitus / therapy
  • Humans
  • Infant, Newborn
  • Insulin-Secreting Cells / metabolism
  • Insulin-Secreting Cells / physiology
  • KATP Channels / genetics
  • KATP Channels / metabolism
  • KATP Channels / physiology
  • Models, Biological
  • Models, Molecular
  • Mutation


  • KATP Channels