Gradual changes in hippocampal activity support remembering the order of events

Neuron. 2007 Nov 8;56(3):530-40. doi: 10.1016/j.neuron.2007.08.017.


The hippocampus is thought to contribute to episodic memory in part by binding stimuli to their spatiotemporal context. The present study examined how hippocampal neuronal populations encode spatial and temporal context as rats performed a task in which they were required to remember the order of trial-unique sequences of odors. The results suggest that a gradual change in the pattern of hippocampal activity served as a temporal context for odor-sampling events and was important for successful subsequent memory of the order of those odors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Cues
  • Hippocampus / physiology*
  • Male
  • Memory / physiology*
  • Neurons / physiology*
  • Neuropsychological Tests
  • Odorants
  • Rats
  • Rats, Long-Evans
  • Reaction Time / physiology
  • Smell / physiology*
  • Synaptic Transmission / physiology
  • Time Factors
  • Time Perception / physiology*