Nickel-catalyzed carboannulation reaction of o-bromobenzyl zinc bromide with unsaturated compounds

Ruixue Deng; Liangdong Sun; Zhi Li

doi:10.1021/ol702167t

Nickel-catalyzed carboannulation reaction of o-bromobenzyl zinc bromide with unsaturated compounds

Org Lett. 2007 Dec 6;9(25):5207-10. doi: 10.1021/ol702167t. Epub 2007 Nov 9.

Authors

Ruixue Deng¹, Liangdong Sun, Zhi Li

Affiliation

¹ Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, People's Republic of China.

PMID: 17990889
DOI: 10.1021/ol702167t

Abstract

A number of indenes have been prepared in good yields by treating o-bromobenzyl zinc bromide 1 with various terminal and internal alkynes in the presence of a nickel catalyst. The nickel-catalyzed carboannulation reaction was successfully extended to the synthesis of indane derivatives by reaction of 1 with acrylates and styrene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bromides / chemical synthesis
Bromides / chemistry*
Carboxylic Acids / chemistry*
Catalysis
Molecular Structure
Nickel / chemistry*
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Zinc Compounds / chemical synthesis
Zinc Compounds / chemistry*

Substances

Bromides
Carboxylic Acids
Organometallic Compounds
Zinc Compounds
o-bromobenzyl zinc bromide
Nickel
zinc bromide