Portal vein thrombosis is a potentially life-threatening condition with occasionally uncertain clinical symptoms and signs. Consequently, the diagnosis may be first made by the radiologist using cross-sectional imaging modalities. A case of extensive portal venous system thrombosis extending into the superior mesenteric vein associated with an unusual pattern of central hepatic enhancement imaged by both 64-slice multidetector CT and 3 Tesla MRI is presented with a discussion of the imaging features of both modalities.