The role of Bach2 in nucleic acid-triggered antiviral innate immune responses

Biochem Biophys Res Commun. 2008 Jan 18;365(3):426-32. doi: 10.1016/j.bbrc.2007.10.183. Epub 2007 Nov 6.


Bach2, a bZIP transcription factor originally identified as interacting with the small Maf family of bZIP proteins, has been shown to play important roles in oxidative stress-mediated cell death. Here, we examine the role of Bach2 in cell death during double-stranded (ds)RNA- and dsDNA-triggered antiviral innate immune responses. Bach2 expression was induced in HeLa cells upon dsRNA/dsDNA treatment and the suppression of Bach2 expression by siRNA treatment alleviated cell death triggered by dsRNA and dsDNA. Unexpectedly, DNA microarray analysis revealed that siRNA-mediated suppression of Bach2 resulted in the attenuated activation of genes involved in the antiviral innate immune response after dsRNA treatment. Our study thus demonstrates a novel role for Bach2 as a key regulator of nucleic acid-triggered antiviral responses in human cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / genetics
  • Basic-Leucine Zipper Transcription Factors / antagonists & inhibitors
  • Basic-Leucine Zipper Transcription Factors / genetics
  • Basic-Leucine Zipper Transcription Factors / physiology*
  • DNA, Viral / immunology*
  • DNA, Viral / pharmacology
  • Gene Expression / drug effects
  • HeLa Cells
  • Humans
  • Immunity, Innate / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Poly I-C / pharmacology
  • RNA, Small Interfering / pharmacology
  • RNA, Viral / immunology*
  • RNA, Viral / pharmacology
  • Viruses / immunology*


  • BACH2 protein, human
  • Basic-Leucine Zipper Transcription Factors
  • DNA, Viral
  • RNA, Small Interfering
  • RNA, Viral
  • Poly I-C