For individuals with obstructive sleep apnea, institution of CPAP therapy is associated with an amelioration of symptoms of depression which is sustained long term

J Clin Sleep Med. 2007 Oct 15;3(6):631-5.


Objective: To assess the sustainability of an improvement in symptoms of depression using CPAP therapy in patients with obstructive sleep apnea.

Patients/methods: Patients referred to our center for evaluation of obstructive sleep apnea who had a respiratory disturbance index (RDI) of > or =15 and who demonstrated a significant response to CPAP (50% or greater drop in RDI), were evaluated for symptoms of depression using the Beck Depression Inventory-Fast Screen for Medical Patients (BDI). These individuals were asked to complete the BDI assessment again after 4 to 6 weeks of treatment with CPAP (short-term follow-up), and then reassessed approximately one year later (long-term follow-up).

Results: In this group of patients, the institution of CPAP therapy resulted in a significant decrease in those symptoms of depression assessed by the BDI at both the short-term and long-term follow-up periods.

Conclusions: For patients with OSA who continue CPAP therapy, we noted a statistically significant, sustained improvement in those symptoms of depression measured by the BDI.

MeSH terms

  • Adult
  • Continuous Positive Airway Pressure*
  • Depression / etiology
  • Depression / therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance
  • Polysomnography
  • Quality of Life*
  • Severity of Illness Index
  • Sleep Apnea, Obstructive / complications
  • Sleep Apnea, Obstructive / diagnosis
  • Sleep Apnea, Obstructive / therapy*
  • Surveys and Questionnaires
  • Treatment Outcome