Maternal nodal and zebrafish embryogenesis

Nature. 2007 Nov 8;450(7167):E1-2; discussion E2-4. doi: 10.1038/nature06314.


In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway. Gore et al. suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.

Publication types

  • Comment

MeSH terms

  • Animals
  • Body Patterning*
  • Embryo, Nonmammalian / metabolism
  • Female
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Models, Biological
  • Mothers
  • Nodal Signaling Ligands
  • Ovary / metabolism
  • Ovum / metabolism
  • RNA Splicing
  • Reproducibility of Results
  • Zebrafish / embryology*
  • Zebrafish / genetics
  • Zebrafish / metabolism
  • Zebrafish Proteins / genetics
  • Zebrafish Proteins / metabolism*


  • Intracellular Signaling Peptides and Proteins
  • Nodal Signaling Ligands
  • Zebrafish Proteins
  • ndr1 protein, zebrafish
  • ndr2 protein, zebrafish