Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats

J Biochem Mol Toxicol. 2007;21(6):336-9. doi: 10.1002/jbt.20199.

Abstract

Increased oxidative stress and antioxidant deficit have been suggested to play a major role in isoproterenol-induced myocardial infarction. The present study was designed to evaluate the effect of alpha-mangostin on the antioxidant defense system and lipid peroxidation against isoproterenol-induced myocardial infarction in rats. Induction of rats with ISO (150 mg/kg body weight, ip) for 2 days resulted in a marked elevation in lipid peroxidation, serum marker enzymes (LDH, CPK, GOT, and GPT) and a significant decrease in the activities of endogenous antioxidants (SOD, CAT, GPx, GST, and GSH). Pre-treatment with alpha-mangostin (200 mg/kg of body weight per day) orally for 6 days prior to the ISO administration and 2 days along with ISO administration significantly attenuated these changes when compared to the individual treatment groups. These findings indicate the protective effect of alpha-mangostin on lipid peroxidation and antioxidant tissue defense system during ISO-induced myocardial infarction in rats.

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Biomarkers / metabolism
  • Cardiotonic Agents / therapeutic use*
  • Garcinia mangostana / metabolism*
  • Isoproterenol
  • Lipid Peroxides
  • Male
  • Myocardial Infarction / chemically induced
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / immunology*
  • Phytotherapy
  • Rats
  • Rats, Wistar
  • Xanthones / therapeutic use*

Substances

  • Antioxidants
  • Biomarkers
  • Cardiotonic Agents
  • Lipid Peroxides
  • Xanthones
  • xanthone
  • Isoproterenol
  • mangostin