Wobble position modified nucleosides evolved to select transfer RNA codon recognition: a modified-wobble hypothesis

P F Agris

doi:10.1016/0300-9084(91)90163-u

Wobble position modified nucleosides evolved to select transfer RNA codon recognition: a modified-wobble hypothesis

Biochimie. 1991 Nov;73(11):1345-9. doi: 10.1016/0300-9084(91)90163-u.

Author

P F Agris¹

Affiliation

¹ Department of Biochemistry, North Carolina State University.

PMID: 1799628
DOI: 10.1016/0300-9084(91)90163-u

Abstract

While recognized that some wobble exists in the base pairing of the first base of the tRNA anticodon with the third of the codon, specific base modifications have evolved to select particular codons. This modified-wobble theory would be exemplified by a single codon recognition imposed on the anticodon by modification of the tRNA wobble position nucleoside.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Codon*
Genetic Code
Models, Genetic
Nucleosides / genetics*
RNA, Transfer / genetics*

Substances

Codon
Nucleosides
RNA, Transfer