Somatostatinergic systems in brain: networks and functions

Mol Cell Endocrinol. 2008 May 14;286(1-2):75-87. doi: 10.1016/j.mce.2007.09.007. Epub 2007 Sep 22.


Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-coupled receptor family. Recent advances in the neuroanatomy of somatostatin neurons and cellular distribution of sst receptors shed light on their functional roles in the neuronal network. Beside their initially described neuroendocrine role, somatostatin systems subserve neuromodulatory roles in the brain, influencing motor activity, sleep, sensory processes and cognitive functions, and are altered in brain diseases like affective disorders, epilepsia and Alzheimer's disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Animals
  • Brain / anatomy & histology
  • Brain / metabolism
  • Brain / physiology*
  • Epilepsy / metabolism
  • Humans
  • Mood Disorders / metabolism
  • Neurotransmitter Agents / physiology*
  • Protein Multimerization
  • Receptors, G-Protein-Coupled / physiology
  • Receptors, Somatostatin / agonists
  • Receptors, Somatostatin / physiology*
  • Signal Transduction
  • Somatostatin / physiology*
  • Spinal Cord / metabolism


  • Neurotransmitter Agents
  • Receptors, G-Protein-Coupled
  • Receptors, Somatostatin
  • Somatostatin