The cell biology of Trypanosoma brucei differentiation

Curr Opin Microbiol. 2007 Dec;10(6):539-46. doi: 10.1016/j.mib.2007.09.014. Epub 2007 Nov 9.


Developmental events in the life-cycle of the sleeping sickness parasite comprise integrated changes in cell morphology, metabolism, gene expression and signalling pathways. In each case these processes differ from the eukaryotic norm. In the past three years, understanding of these developmental processes has progressed from a description of the cytological events of differentiation to a discovery of its underlying molecular controls. With an expanding set of reagents for the identification of distinct parasite life-cycle stages in the tsetse, trypanosome differentiation is being studied from the molecular to the organismal and population level. Interestingly, the new molecular discoveries provide insights into the biology of the parasite in the field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Life Cycle Stages* / genetics
  • Life Cycle Stages* / physiology
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism
  • Trypanosoma brucei brucei / cytology
  • Trypanosoma brucei brucei / genetics
  • Trypanosoma brucei brucei / growth & development*
  • Trypanosoma brucei brucei / metabolism
  • Tsetse Flies / parasitology


  • Protozoan Proteins