Impact of visual field loss on health-related quality of life in glaucoma: the Los Angeles Latino Eye Study

Ophthalmology. 2008 Jun;115(6):941-948.e1. doi: 10.1016/j.ophtha.2007.08.037. Epub 2007 Nov 12.


Purpose: To examine the association between health-related quality of life (HRQOL) and visual field (VF) loss in participants with open-angle glaucoma (OAG) in the Los Angeles Latino Eye Study (LALES).

Design: Population-based cross-sectional study.

Participants: Two hundred thirteen participants with OAG and 2821 participants without glaucoma or VF loss.

Methods: Participants in the LALES-a population-based prevalence study of eye disease in Latinos 40 years and older, residing in Los Angeles, California-underwent a detailed eye examination including an assessment of their VF using the Humphrey Automated Field Analyzer (Swedish interactive thresholding algorithm Standard 24-2). Open-angle glaucoma was determined by clinical examination. Mean deviation scores were used to assess severity of VF loss. Health-related QOL was assessed by the Medical Outcomes Study 12-item Short-Form Health Survey (SF-12) and 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). Linear regression and analysis of covariance were used to assess the relationship between HRQOL scores and VF loss after adjusting for sociodemographic variables and visual acuity.

Main outcome measures: The 25-item NEI-VFQ and SF-12 scores.

Results: A trend of worse NEI-VFQ-25 scores for most subscales was observed with worse VF loss (using both monocular and calculated binocular data). Open-angle glaucoma participants with VF loss had lower scores than participants with no VF loss. This association was also present in participants who were previously undiagnosed and untreated for OAG (N = 160). Participants with any central VF loss had lower NEI-VFQ-25 scores than those with unilateral or bilateral peripheral VF loss. There was no significant impact of severity or location of VF loss on SF-12 scores.

Conclusion: Greater severity of VF loss in persons with OAG impacts vision-related QOL. This impact was present in persons who were previously unaware that they had glaucoma. Prevention of VF loss in persons with glaucoma is likely to reduce loss of vision-related QOL.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Glaucoma, Open-Angle / ethnology
  • Glaucoma, Open-Angle / psychology*
  • Health Status*
  • Hispanic or Latino / ethnology*
  • Humans
  • Los Angeles / epidemiology
  • Male
  • Middle Aged
  • Quality of Life / psychology*
  • Sickness Impact Profile
  • Surveys and Questionnaires
  • Vision Disorders / ethnology
  • Vision Disorders / psychology*
  • Visual Acuity / physiology
  • Visual Fields*
  • Visually Impaired Persons / psychology*