Divergent approach for synthesis and terminal modifications of dendritic polyphenylazomethines

Kensaku Takanashi; Kimihisa Yamamoto

doi:10.1021/ol701925a

Divergent approach for synthesis and terminal modifications of dendritic polyphenylazomethines

Org Lett. 2007 Dec 6;9(25):5151-4. doi: 10.1021/ol701925a. Epub 2007 Nov 13.

Authors

Kensaku Takanashi¹, Kimihisa Yamamoto

Affiliation

¹ Department of Chemistry, Faculty of Science & Technology, Keio University, Yokohama 223-8522, Japan.

PMID: 17997561
DOI: 10.1021/ol701925a

Abstract

In the past, dendritic polyphenylazomethines (DPA) have been synthesized via the convergent method. However, the convergent method has problems such as difficult terminal-group modifications and an increased number of steps. Therefore, we synthesized the terminal-protected DPA to construct the dendritic structure via the divergent method. The combination of the convergent method and the divergent method easily achieved the rapid synthesis of a higher generation dendrimer. Furthermore, we succeeded in the synthesis of the water-soluble PEG-DPA via the divergent method using the ester-DPA.