Hypoxia and the unfolded protein response

Methods Enzymol. 2007;435:275-93. doi: 10.1016/S0076-6879(07)35014-3.

Abstract

Tumor hypoxia refers to the development of regions within solid tumors in which the oxygen concentration is lower (0-3%) compared to that in most normal tissues (4-9%) (Vaupel and Hockel, 2000). Considerable experimental and clinical evidence exists supporting the notion that hypoxia fundamentally alters the physiology of the tumor towards a more aggressive phenotype (Hockel and Vaupel, 2001). Therefore, delineating the mechanisms by which hypoxia affects tumor physiology at the cellular and molecular levels will be crucial for a better understanding of tumor development and metastasis and for designing better antitumor modalities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activating Transcription Factor 4 / metabolism
  • Anaerobiosis
  • Animals
  • Cell Hypoxia
  • Cell Line, Tumor
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Endoplasmic Reticulum / metabolism*
  • Endoribonucleases / metabolism
  • Eukaryotic Initiation Factor-2 / metabolism
  • Humans
  • Luminescent Measurements / methods*
  • Membrane Proteins / metabolism
  • Mice
  • Neoplasms / metabolism*
  • Oxygen / metabolism*
  • Protein Folding*
  • Protein-Serine-Threonine Kinases / metabolism
  • Proteins / analysis*
  • Regulatory Factor X Transcription Factors
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • eIF-2 Kinase / metabolism

Substances

  • DNA-Binding Proteins
  • Eukaryotic Initiation Factor-2
  • Membrane Proteins
  • Proteins
  • Regulatory Factor X Transcription Factors
  • Transcription Factors
  • Activating Transcription Factor 4
  • ERN2 protein, human
  • PERK kinase
  • Protein-Serine-Threonine Kinases
  • eIF-2 Kinase
  • Endoribonucleases
  • Oxygen