Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects

Arch Neurol. 2007 Nov;64(11):1672-3. doi: 10.1001/archneur.64.11.1672.
No abstract available

Publication types

  • Clinical Trial
  • Letter

MeSH terms

  • Adult
  • Aged
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / metabolism*
  • Apolipoprotein E4 / genetics
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Male
  • Middle Aged
  • Mutation / genetics
  • Peptide Fragments / metabolism
  • Presenilin-1 / genetics*
  • Time Factors

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Apolipoprotein E4
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • PSEN1 protein, human
  • Peptide Fragments
  • Presenilin-1
  • amyloid beta-protein (1-42)