The BioGRID Interaction Database: 2008 Update

Nucleic Acids Res. 2008 Jan;36(Database issue):D637-40. doi: 10.1093/nar/gkm1001. Epub 2007 Nov 13.

Abstract

The Biological General Repository for Interaction Datasets (BioGRID) database (http://www.thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for both the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase and Entrez Gene. Source code for the BioGRID and the linked Osprey network visualization system is now freely available without restriction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / metabolism
  • Database Management Systems
  • Databases, Genetic*
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Gene Regulatory Networks*
  • Humans
  • Internet
  • Mice
  • Protein Interaction Mapping*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces pombe Proteins / metabolism
  • User-Computer Interface

Substances

  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins