TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

Nat Rev Mol Cell Biol. 2007 Dec;8(12):970-82. doi: 10.1038/nrm2297.

Abstract

Ligands of the transforming growth factor-beta (TGFbeta) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions. Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms. Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes. An equally important challenge is understanding the functional role of signal strength and duration. How are these quantitative aspects of the extracellular signal regulated? How are they then sensed and interpreted, and how do they affect responses?

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Signal Transduction*
  • Smad Proteins / chemistry
  • Smad Proteins / metabolism*
  • Transforming Growth Factor beta / chemistry*
  • Transforming Growth Factor beta / metabolism*

Substances

  • Smad Proteins
  • Transforming Growth Factor beta