Method for assessing the similarity between subsets of the T cell receptor repertoire

J Immunol Methods. 2008 Jan 1;329(1-2):67-80. doi: 10.1016/j.jim.2007.09.016. Epub 2007 Oct 29.


The CD8+ T cell response is important in the control of many viral and other infections. There have been many studies aimed at better understanding the influence of T cell receptor diversity on immune responses and the evolution of the T cell receptor repertoire over time and through the various stages of immune responses to infection. In recent years, there has been an increase in both the number of studies using T cell receptor data and the volume of T cell receptor data generated per study. Appropriate analytical tools are required to analyse this data. We present a robust approach to assessing the similarity between samples of the T cell receptor repertoire, which we demonstrate on published data of subsets of the influenza A virus D(b)NP366(-) and D(b)PA224(-)specific CD8+ T cell responses in mice sorted on the expression of CD62L, which is a marker distinguishing central and effector memory cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / virology
  • Computational Biology*
  • Disease Models, Animal
  • Immunologic Memory*
  • Influenza A virus
  • L-Selectin / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Models, Immunological*
  • Orthomyxoviridae Infections / immunology*
  • Orthomyxoviridae Infections / virology
  • Receptors, Antigen, T-Cell / metabolism*
  • Time Factors


  • Receptors, Antigen, T-Cell
  • L-Selectin