Intermittent pneumatic compression (IPC) is widely used for deep vein thrombosis (DVT) prophylaxis. The technique involves periodic inflation of a compression cuff around a limb, which acts to simulate the muscle pump mechanism, encouraging venous blood flow. However, there is uncertainty regarding the relationship between compression, vascular effects and clinical outcomes. This study investigates calf compression provided by four IPC cuffs with different air bladder configurations. Interface pressure between the cuff and the skin surface is measured and magnetic resonance (MR) images are obtained showing the calf cross section before and during compression. The data will be used to inform numerical simulations of IPC, leading to increased understanding of the implications of cuff design in relation to IPC and DVT prophylaxis.