Sex-linked Deafness

Clin Genet. 2008 Jan;73(1):14-23. doi: 10.1111/j.1399-0004.2007.00913.x. Epub 2007 Nov 13.


Many human syndromes associated with hearing loss are caused by disease genes located on the X chromosome, but few X-linked loci for non-syndromic hearing loss have been reported. Surprisingly, a Y-linked locus has been identified, representing one of the only disease loci on the Y chromosome. This study reviews the different sex-linked genes and loci on the X- and Y chromosome leading to syndromic and especially non-syndromic hearing loss.

Publication types

  • Review

MeSH terms

  • Chromosome Mapping
  • Deafness / genetics
  • Genetic Diseases, X-Linked*
  • Genetic Diseases, Y-Linked*
  • Hearing Loss / classification
  • Hearing Loss / genetics*
  • Humans
  • Mutation
  • Syndrome