ALIX catches HIV

Cell Host Microbe. 2007 Mar 15;1(1):5-7. doi: 10.1016/j.chom.2007.02.006.

Abstract

ESCRT and ESCRT-associated proteins are required during the assembly and release of many RNA viruses, including HIV. Two new papers provide structures for the ESCRT-associated protein ALIX/AIP1 and demonstrate how this protein interacts with HIV Gag. One of these studies provides the clearest evidence to date that ESCRT-III mediates key events in virus release and indicates that there are cellular proteins involved in this process still to be discovered.

MeSH terms

  • Animals
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / metabolism*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Endosomal Sorting Complexes Required for Transport
  • Endosomes / metabolism
  • Gene Products, gag / genetics
  • Gene Products, gag / metabolism
  • HIV / metabolism*
  • HIV / ultrastructure
  • HIV Infections / metabolism*
  • Humans
  • Proteins / genetics
  • Proteins / metabolism*
  • Virus Assembly

Substances

  • Calcium-Binding Proteins
  • Carrier Proteins
  • Cell Cycle Proteins
  • Endosomal Sorting Complexes Required for Transport
  • Gene Products, gag
  • PDCD6IP protein, human
  • Proteins
  • MAGI2 protein, human