Influenza A virus PB1-F2: a small protein with a big punch

Cell Host Microbe. 2007 Oct 11;2(4):207-9. doi: 10.1016/j.chom.2007.09.010.


Virulence factors, such as the recently discovered PB1-F2, contribute to the pathogenesis and comorbidity of influenza A virus. In this issue of Cell Host & Microbe, McAuley et al. characterize the role of PB1-F2, including in the pandemic 1918 virus, in causing increased lung pathology and fatal pneumococcus infection in mice. This work sheds light on the mechanisms of pathogenicity during influenza A virus infections.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Humans
  • Influenza A virus / chemistry*
  • Influenza A virus / pathogenicity
  • Lung / pathology
  • Mice
  • Orthomyxoviridae Infections / complications
  • Orthomyxoviridae Infections / pathology
  • Orthomyxoviridae Infections / virology*
  • Pneumonia, Pneumococcal / complications
  • Pneumonia, Pneumococcal / pathology
  • Viral Proteins / physiology*
  • Virulence


  • PB1-F2 protein, Influenza A virus
  • Viral Proteins