Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients

J Prosthet Dent. 1991 Sep;66(3):361-9. doi: 10.1016/0022-3913(91)90264-w.


Oral mucositis is among the complications of head and neck irradiation and systemic chemotherapy. To determine whether or not mucositis could be prevented or reduced in intensity by using Kamillosan Liquidum as an oral rinse, 98 patients were placed on study protocols. Twenty patients who were treated with radiation therapy and 46 patients who received systemic chemotherapy participated in prophylactic oral care with Kamillosan oral rinse. Thirty-two patients were treated therapeutically after mucositis had developed. Sixteen patients receiving chemotherapy were treated therapeutically and prophylactically with Kamillosan oral rinse during repeated cycles of chemotherapy. Only one of the 20 patients who had had radiation therapy developed grade 3 mucositis in the final week of treatment. Thirty-six of the 46 patients undergoing chemotherapy did not develop clinically noticeable mucositis. It appears that resolution of mucositis is accelerated by Kamillosan rinse. Prophylactic oral care appeared to modify the oral environment favorably and maintain tissue integrity.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Azulenes
  • Cycloheptanes / therapeutic use*
  • Drug Combinations
  • Flavonoids / therapeutic use
  • Head and Neck Neoplasms / drug therapy*
  • Head and Neck Neoplasms / radiotherapy*
  • Humans
  • Middle Aged
  • Monocyclic Sesquiterpenes
  • Mouth Mucosa / drug effects
  • Mouth Mucosa / pathology
  • Mouth Mucosa / radiation effects
  • Mouthwashes / therapeutic use*
  • Oils, Volatile / therapeutic use*
  • Oral Hygiene
  • Plant Extracts / therapeutic use*
  • Radiotherapy / adverse effects
  • Radiotherapy Dosage
  • Sesquiterpenes / therapeutic use*
  • Stomatitis / chemically induced
  • Stomatitis / etiology
  • Stomatitis / pathology
  • Stomatitis / prevention & control*


  • Azulenes
  • Cycloheptanes
  • Drug Combinations
  • Flavonoids
  • Kamillosan Liquidum
  • Monocyclic Sesquiterpenes
  • Mouthwashes
  • Oils, Volatile
  • Plant Extracts
  • Sesquiterpenes
  • bisabolol
  • chamazulene