An efficient protocol for the solid-phase synthesis of malondiamides

Molecules. 2005 Dec 31;10(12):1438-45. doi: 10.3390/10121438.


A novel and straightforward solid-phase synthesis of malondiamides containing a free nitrogen has been developed. These intermediates, which can be directly obtained in good yield and purity, can be further derivatised. This approach can be used for the synthesis of large split-and-mix-libraries.

MeSH terms

  • Diamide / chemical synthesis*
  • Diamide / chemistry
  • Malonates / chemical synthesis*
  • Malonates / chemistry
  • Nitrogen / chemistry
  • Polymers / chemistry


  • Malonates
  • Polymers
  • Diamide
  • Nitrogen