Recognizing and exploiting differences between RNAi and small-molecule inhibitors

Nat Chem Biol. 2007 Dec;3(12):739-44. doi: 10.1038/nchembio1207-739.


The biology of RNA interference has greatly facilitated analysis of loss-of-function phenotypes, but correlating these phenotypes with small-molecule inhibition profiles is not always straightforward. We examine the rationale of comparing RNA interference to pharmacological intervention in chemical biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Lipid Metabolism
  • Phenotype
  • Phosphotransferases / antagonists & inhibitors
  • Phosphotransferases / genetics
  • Phosphotransferases / metabolism
  • Protein Kinase Inhibitors / pharmacology*
  • RNA Interference*


  • Protein Kinase Inhibitors
  • Phosphotransferases